Inés Marin



MMRES student at IRB Barcelona
Class 2017-2018

After MMRES:

PhD at IRB Barcelona

Both tissue-intrinsic and systemic BMAL1 are essential to maintain the homeostasis of the epidermis


BMAL1 deficiency leads to a premature epidermal aging due to deregulation of the homeostasis of the tissue that starts as early as 8 weeks of age. Exclusive expression of Bmal1 in the epidermis importantly rescues this phenotype independently, at least in part, of its circadian rhythmicity. However, systemic Bmal1 expression is required to completely assure that epidermal fitness is maintained.

Major project supervisor

Salvador Benitah
IRB Barcelona

Minor project supervisor

Núria López-Bigas
IRB Barcelona